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Signal transduction in the post-genomic era
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Nancy R. Gough, Ph.D.
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【要 旨】
Understanding the processes by which cells and organisms respond and adapt to their (internal or external) environment will allow scientists and clinicians to develop more selective therapeutics with minimal side effects. Aberrant signaling processes underlie many disease states and signaling components are the targets of many therapeutic agents. The challenge faced by scientists now is to begin to grasp the complexity and interconnectedness of the cellular signaling pathways to understand how altering one element will affect the cellular or organismal response. New techniques (advances in high throughput screening for protein interactions or substrates, genome analysis, and real-time visualization of signaling processes) along with new disciplines (engineering and mathematical modeling) will be needed to solve this puzzle. Science and Science's STKE are at the leading edge of this process, providing tools and new formats for accessing information and understanding the expanding world of signal transduction. |
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 Nancy
R. Gough, Ph.D.
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